3MCC Deficiency
Description
Clinical Characteristics
Without treatment, recurring metabolic crises associated with illness may result in developmental delays, failure to thrive, or seizures. Symptoms generally begin after three months and before three years of age. Affected children may be healthy between metabolic crises. Some people remain completely asymptomatic.
- Poor feeding
- Vomiting
- Irritability
- Lethargy
- Lab findings:
- Hyperammonemia
- Low carnitine levels
- Ketoacidosis
- Hypoglycemia
- Hyperglycemia
- Failure to thrive
- Fasting intolerance
- Hypotonia
- Reye-like illness
- Seizures
- Coma
- Developmental delay/intellectual disability
Primary Care Management
Next Steps After a Positive Screen
- Contact the family and evaluate the infant for poor feeding, vomiting, or lethargy.
- Provide emergency treatment/referral for symptoms of hypoglycemia, metabolic acidosis, or seizures.
Confirming the Diagnosis
- To confirm the diagnosis of 3MCC deficiency, work with Newborn Screening Services (see NV providers [2]).
- Follow-up testing will include quantitative plasma acylcarnitine profile, serum biotinidase, urine organic acids, and enzyme activity assay in white blood cells.
If the Diagnosis is Confirmed
- For evaluation and ongoing collaborative management, consult Biochemical Genetics (Metabolics) Clinics (see NV providers [2]).
- Educate the family regarding signs, symptoms, and the need for urgent care when the infant becomes ill. See 3MCC Deficiency - Information for Parents (STAR-G).
- Once a diagnosis is confirmed, endocrine testing is completed. Then, long-term care requires a specialist team and testing on a repeating basis (endocrine testing and brain MRIs for males).
- Oral L-carnitine supplementation
- Fasting avoidance, low-protein diet in rare cases
- For those identified after irreversible consequences, assist in management, particularly with developmental and educational interventions.
Resources
Information & Support
After a Diagnosis or Problem is Identified
Families can face a big change when their baby tests positive for a newborn condition. Find information about A New Diagnosis - You Are Not Alone; Caring for Children with Special Health Care Needs; Assistance in Choosing Providers; Partnering with Healthcare Providers; Top Ten Things to Do After a Diagnosis.
For Professionals
3-Methylchrotonyl-CoA (3-MCC) Dehydrogenase Deficiency (NECMP)
A guideline for health care professionals treating the sick infant/child who has previously been diagnosed with 3MCCD; developed
under the direction of Dr. Harvey Levy, Senior Associate in Medicine/Genetics at Children’s Hospital Boston, and Professor
of Pediatrics at Harvard Medical School, for the New England Consortium of Metabolic Programs.
3MCC Deficiency (OMIM)
Information about clinical features, diagnosis, management, and molecular and population genetics; Online Mendelian Inheritance
in Man, authored and edited at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
For Parents and Patients
Support
Organic Acidemia Association (OAA)
A nonprofit organization that provides information, support, events, connections with other parents, a discussion board,
and nutrition and recipe ideas.
General
3MCC Deficiency - Information for Parents (STAR-G)
A fact sheet, written by a genetic counselor and reviewed by metabolic and genetic specialists, for families who have received
an initial diagnosis of this newborn disorder; Screening, Technology and Research in Genetics.
3-methylcrotonyl-CoA carboxylase deficiency (MedlinePlus)
Information for families that includes description, frequency, causes, inheritance, other names, and additional resources;
from the National Library of Medicine.
Resources for 3MCC Deficiency (Disease InfoSearch)
Compilation of information, articles, and links to support; from Genetic Alliance.
Tools
NV ACT Sheet for 3MCC Deficiency (ACMG) (
125 KB)
Contains short-term recommendations for clinical follow-up of the newborn who has screened positive, along with resources
for consultation and patient education/support; from the American College of Genetics and Genomics
Confirmatory Algorithms for Elevated C5-OH (ACMG) ( 224 KB)
Basic steps involved in determining the final diagnosis of an infant with a positive newborn screen for this condition; American
College of Medical Genetics.
Services for Patients & Families in Nevada (NV)
| Service Categories | # of providers* in: | NV | NW | Other states (4) (show) | | NM | OH | RI | UT |
|---|---|---|---|---|---|---|---|---|---|
| Biochemical Genetics (Metabolics) Clinics | 2 | 1 | 2 | 1 | 1 | 3 | |||
| Medical Genetics | 5 | 1 | 2 | 1 | 4 | 6 | |||
| Newborn Screening Services | 2 | 1 | 3 | 2 | 2 | 3 | |||
For services not listed above, browse our Services categories or search our database.
* number of provider listings may vary by how states categorize services, whether providers are listed by organization or individual, how services are organized in the state, and other factors; Nationwide (NW) providers are generally limited to web-based services, provider locator services, and organizations that serve children from across the nation.
Helpful Articles
PubMed search for 3MCC deficiency and neonatal screening, last 10 years.
Pasquali M, Monsen G, Richardson L, Alston M, Longo N.
Biochemical findings in common inborn errors of metabolism.
Am J Med Genet C Semin Med Genet.
2006;142C(2):64-76.
PubMed abstract
Page Bibliography
Schulze A, Lindner M, Kohlmuller D, Olgemoller K, Mayatepek E, Hoffmann GF.
Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome,
and implications.
Pediatrics.
2003;111(6 Pt 1):1399-406.
PubMed abstract