Professor of Psychiatry, Behavioral Sciences and Pediatrics
Departments of Psychiatry & Behavioral Sciences and Pediatrics
Kansas University Medical Center

Chairperson, Research Committee
Heartland Regional Genetics and Newborn Screening Collaborative

Chair, Scientific Advisory Board
Prader-Willi Syndrome Association (USA)

3901 Rainbow Blvd, MS 4015
Kansas City, KS 66160
contact address


Dr. Butler is engaged in the clinical genetics practice of children and adults presenting for genetics services with emphasis on genetic disorders, developmental disabilities, congenital anomalies, cytogenetic syndromes, Prader-Willi syndrome, early onset of morbid obesity and autism. His research interests include the genetics of obesity with emphasis on Prader-Willi syndrome and obesity-related disorders, autism, psychiatric and behavioral genetics, genotype-phenotype correlations and the natural history and delineation of rare and uncommon clinical genetics syndromes. From 1998 to 2008, he was appointed Section Chief of Medical Genetics and Molecular Medicine at Children's Mercy Hospital and Professor of Pediatrics, University of Missouri - Kansas City School of Medicine and in 2008, he was appointed Professor of Psychiatry & Behavioral Sciences and Pediatrics and Director, Division of Research, University of Kansas Medical Center.

He has been an active member of several professional organizations including NIH study sections, editorial boards for journals, and conducted extramurally funded research on Prader-Willi, Angelman and fragile X syndromes, the genetics of autism and obesity and delineation of genetic disorders. He has published over 400 research articles, multiple book chapters and edited several journal issues and two textbooks.

No conflicts of interest (07/08/2022).

Selected Bibliography:

Proffitt J, Osann K, McManus B, Kimonis VE, Heinemann J, Butler MG, Stevenson DA, Gold JA.
Contributing factors of mortality in Prader-Willi syndrome.
Am J Med Genet A. 2019;179(2):196-205. PubMed abstract / Full Text

Mahmoud R, Singh P, Weiss L, Lakatos A, Oakes M, Hossain W, Butler MG, Kimonis V.
Newborn screening for Prader-Willi syndrome is feasible: Early diagnosis for better outcomes.
Am J Med Genet A. 2019;179(1):29-36. PubMed abstract / Full Text

Singh P, Mahmoud R, Gold JA, Miller JL, Roof E, Tamura R, Dykens E, Butler MG, Driscoll DJ, Kimonis V.
Multicentre study of maternal and neonatal outcomes in individuals with Prader-Willi syndrome.
J Med Genet. 2018;55(9):594-598. PubMed abstract / Full Text

Butler MG, Kimonis V, Dykens E, Gold JA, Miller J, Tamura R, Driscoll DJ.
Prader-Willi syndrome and early-onset morbid obesity NIH rare disease consortium: A review of natural history study.
Am J Med Genet A. 2018;176(2):368-375. PubMed abstract / Full Text

Manzardo AM, Loker J, Heinemann J, Loker C, Butler MG.
Survival trends from the Prader-Willi Syndrome Association (USA) 40-year mortality survey.
Genet Med. 2018;20(1):24-30. PubMed abstract / Full Text